SNP rs7549881, near SGIP1 at 1p31.3, is significantly associated with digestive disorders and Parkinsonism in women
SNP rs7549881 is associated with PD in females and with gastrointestinal disorders across both sexes. These findings reinforce the role of SGIP1 in synaptic endocytosis and suggest its contribution to gut-brain axis dysfunction in PD.
Authors
- Peter H. Rheinstein (ORCID: https://orcid.org/0000-0002-4608-1665)
- Steven P. Lehrer (ORCID: https://orcid.org/0000-0002-4850-094X)
Institutions
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Clinical Parkinsonism & Related Disorders
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.prdoa.2025.100391
- Primary Topic
- Biochemical Analysis and Sensing Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Icahn School of Medicine at Mount Sinai
- National Center for Advancing Translational Sciences