A Redundant System of Thioredoxin and Glutathione Is Essential for Pancreatic Acinar Integrity
These findings indicate that the response to AP is closely linked to alterations in antioxidant systems. The thioredoxin and the glutathione systems appear to perform overlapping protective roles in safeguarding acinar cells during AP. A simultaneous disruption of both systems proves detrimental to pancreatic integrity during acute pancreatitis.
Authors
- Henrik Einwächter (ORCID: https://orcid.org/0000-0002-8823-5116)
- Markus Brielmeier (ORCID: https://orcid.org/0000-0002-8715-869X)
- Mariana Rickmann (ORCID: https://orcid.org/0000-0003-0620-172X)
- Michaela Aichler
- Nirav Florian Chhabra (ORCID: https://orcid.org/0000-0002-6231-8423)
- Rupert Oellinger
- Roland M. Schmid (ORCID: https://orcid.org/0000-0002-5751-7313)
- Bailing Li (ORCID: https://orcid.org/0000-0003-4070-5913)
Institutions
- TUM Klinikum (DE)
- Helmholtz Zentrum München (DE)
- Technical University of Munich (DE)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101627
- Citations
- 2
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.01