Microbiota-dependent Formylated Peptide Receptor (Fpr1/2) Signaling Regulates Enteric Nervous System Development and Gastrointestinal Motility in Mice
Collectively our data show that microbiota-Fpr1/2 signaling in the murine gut is critical for normal ENS development and GI motility and identify Fpr1/2 as a potential therapeutic target to correct GI hypomotility. Our data also suggests a cautious approach to antibiotic usage during pregnancy.
Authors
- Alexandra A. Wolfarth (ORCID: https://orcid.org/0000-0001-7902-8935)
- Andrew J. Macpherson (ORCID: https://orcid.org/0000-0002-7192-0184)
- Amanda Metzger
- Caroline Addis
- Charlie Smoller
- Rheinallt M. Jones (ORCID: https://orcid.org/0000-0002-0415-9487)
- Huixia Wu (ORCID: https://orcid.org/0000-0002-3945-542X)
- Andrew S. Neish
- Bindu Chandrasekharan (ORCID: https://orcid.org/0000-0003-2943-3902)
- Darra Boyer
- Richard U. Eboka
- Shanthi Srinivasan (ORCID: https://orcid.org/0000-0002-6275-2369)
- Ji-Young Kim (ORCID: https://orcid.org/0000-0002-0536-0035)
- Ken Liu (ORCID: https://orcid.org/0000-0002-9736-5828)
Institutions
- University of Bern (CH)
- Bern University of Applied Sciences (CH)
- Emory University (US)
- Emory University Hospital (US)
- Atlanta VA Medical Center (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101624
- Citations
- 1
- Primary Topic
- Pediatric health and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.52