Optimizing cardiac diffusion tensor imaging in vivo: More directions or repetitions?
We observed that accuracy and precision were enhanced by (i) prioritizing number of diffusion encoding directions over NR given a fixed acquisition time, (ii) acquiring sufficient low b-value data, and (iii) using longer protocols where feasible. For clinically relevant protocols, our findings support the use of ND = 30 and NA<sub>b50</sub>:NA<sub>b500</sub> ≥ 1/3 for better accuracy and precision in cDTI parameters. These findings are intended to help guide protocol optimization for harmonization of cDTI.
Authors
- Noor Sharrack (ORCID: https://orcid.org/0000-0001-5880-1722)
- Jürgen E. Schneider (ORCID: https://orcid.org/0000-0003-0999-5684)
- Richard Foster (ORCID: https://orcid.org/0000-0002-2361-3884)
- Maryam Afzali (ORCID: https://orcid.org/0000-0003-3378-0878)
- Christopher Nguyen (ORCID: https://orcid.org/0000-0003-3347-1530)
- Sam Coveney (ORCID: https://orcid.org/0000-0002-7134-3196)
- Erica Dall’Armellina (ORCID: https://orcid.org/0000-0002-2165-7154)
- David Shelley
- Irvin Teh (ORCID: https://orcid.org/0000-0002-6705-3129)
- Sven Plein (ORCID: https://orcid.org/0000-0002-0997-4384)
- Ana‐Maria Poenar (ORCID: https://orcid.org/0000-0002-9281-5025)
Institutions
- University of Leeds (GB)
- Cleveland Clinic (US)
- Leeds Teaching Hospitals NHS Trust (GB)
- Cardiff University (GB)
Publication Details
- Journal
- Journal of Cardiovascular Magnetic Resonance
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jocmr.2025.101951
- Citations
- 1
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- Wellcome Trust
- British Heart Foundation