Deubiquitinase Josephin Domain-containing Protein 2 Promotes Acute Pancreatitis by Removing K63-linked Poly-ubiqutin Chain on Proliferating Cell Nuclear Antigen in Pancreatic Acinar Cells
JOSD2 regulates AP progression via PCNA-mediated DNA damage response and may serve as a promising therapeutic target for AP treatment.
Authors
- Yi Fang (ORCID: https://orcid.org/0000-0002-9715-7236)
- Lijun Ji
- Wu Luo (ORCID: https://orcid.org/0000-0003-3827-1159)
- Guang Liang (ORCID: https://orcid.org/0000-0002-8278-849X)
- Yaqian Cui
- Xin Liu (ORCID: https://orcid.org/0009-0006-2118-3549)
- Xiang Hu (ORCID: https://orcid.org/0000-0001-5329-6907)
- Yongqiang Xiong (ORCID: https://orcid.org/0000-0003-4175-0097)
- Qingsong Zheng
- Taile Jing (ORCID: https://orcid.org/0000-0002-0294-5652)
- Jiaxi Ye
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101621
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Medical and Health Research Project of Zhejiang Province
- Natural Science Foundation of Zhejiang Province