(20S)-protopanaxatriol attenuates Ang II-induced renal injury via PTPN1-mediated AMPK/mTOR signaling pathway
These findings validate ginseng's traditional use in kidney disorders and demonstrate PPT's potential as a therapeutic agent for hypertensive nephropathy by targeting PTPN1/AMPK/mTOR signaling. Further clinical exploration is needed to translate these results into practice.
Authors
- Haiming Sun (ORCID: https://orcid.org/0000-0002-6296-7992)
- Hao-Fei Du
- Mengyang Wang (ORCID: https://orcid.org/0000-0002-5364-3320)
- Shengyu Yan (ORCID: https://orcid.org/0009-0004-4256-1209)
- Zhuoqun Wang (ORCID: https://orcid.org/0000-0003-1839-8419)
- Chang Liu (ORCID: https://orcid.org/0000-0002-9306-2475)
- Min Zhang (ORCID: https://orcid.org/0000-0002-7023-8781)
- Wei Liu (ORCID: https://orcid.org/0000-0002-7568-5521)
- Linxin Zhang
- Gege Yang
- Risheng Zhao (ORCID: https://orcid.org/0000-0002-1269-9205)
Institutions
- Beihua University (CN)
Publication Details
- Journal
- Journal of Ginseng Research
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1016/j.jgr.2025.08.009
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China