Prospective Multicenter Longitudinal Measurement of Liver Stiffness in School-Age Children With Cholestatic Liver Disease
Surprisingly, longitudinal measurement of LSM and laboratory parameters of liver disease severity over 2 years in school-age children with compensated BA, a1-AT, and ALGS did not reveal significant change, consistent with slow progression of cholestatic liver disease in this age group. These findings have implications for both clinical care and interventional trials in this patient population.
Authors
- Kasper Wang
- Laurel Cavallo (ORCID: https://orcid.org/0000-0002-8531-840X)
- Ronald J. Sokol (ORCID: https://orcid.org/0000-0001-7433-4095)
- Saul J. Karpen (ORCID: https://orcid.org/0000-0002-3379-7592)
- Alexander Gerhard Miethke (ORCID: https://orcid.org/0000-0003-1395-9475)
- Benjamin L. Shneider (ORCID: https://orcid.org/0000-0002-7208-0949)
- Jeffrey Teckman (ORCID: https://orcid.org/0000-0002-4870-2621)
- Pamela L. Valentino (ORCID: https://orcid.org/0000-0002-8227-2004)
- M Kyle Jensen
- Jean Pappas Molleston (ORCID: https://orcid.org/0000-0002-8708-0298)
- Nathan P. Goodrich (ORCID: https://orcid.org/0000-0003-0392-7146)
- John C. Magee (ORCID: https://orcid.org/0000-0001-8416-7905)
- Shikha S. Sundaram (ORCID: https://orcid.org/0000-0003-2523-6389)
- Jorge A. Bezerra (ORCID: https://orcid.org/0000-0001-9667-7742)
- James E. Squires (ORCID: https://orcid.org/0000-0001-6979-8987)
- Kathleen M. Loomes (ORCID: https://orcid.org/0000-0002-1539-6672)
- Binita Maya Kamath (ORCID: https://orcid.org/0000-0002-9982-5023)
- René Romero (ORCID: https://orcid.org/0000-0002-1566-2280)
- Philip Rosenthal (ORCID: https://orcid.org/0000-0001-7840-5401)
- Lee M. Bass (ORCID: https://orcid.org/0000-0003-1253-714X)
- Wen Ye (ORCID: https://orcid.org/0000-0001-5802-189X)
- Daniel H. Leung (ORCID: https://orcid.org/0000-0002-2139-5959)
- Rohit Kohli
Institutions
- Northwestern University (US)
- University of Southern California (US)
- Cincinnati Children's Hospital Medical Center (US)
- Seattle Children's Hospital (US)
- Primary Children's Hospital (US)
- Children's Hospital of Philadelphia (US)
- University of California, San Francisco (US)
- Virginia Commonwealth University (US)
- University of Washington (US)
- University of Michigan (US)
- Hospital for Sick Children (CA)
- Riley Hospital for Children (US)
- Cardinal Glennon Children’s Medical Center (US)
- Children's Hospital Colorado (US)
- Children's Hospital of Pittsburgh (US)
- Arbor Research Collaborative for Health (US)
- Children's Healthcare of Atlanta (US)
- Texas Children's Hospital (US)
- Indiana University – Purdue University Indianapolis (US)
- The University of Texas Southwestern Medical Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Gastro Hep Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.gastha.2025.100788
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Center for Advancing Translational Sciences