Preeclampsia is associated with placental complement C4d deposition
Our data demonstrate an increase in C4d deposition in placentas of early onset preeclampsia compared to healthy term controls and spontaneous preterm births, suggesting a possible role for the complement system in preeclampsia. Our findings underscore the complexity of preeclampsia pathophysiology and highlight the need for more refined, subtype-specific investigations.
Authors
- Esther Pierik (ORCID: https://orcid.org/0000-0002-9570-2878)
- Sanne J. Gordijn (ORCID: https://orcid.org/0000-0003-3915-8609)
- Mohamed R. Daha (ORCID: https://orcid.org/0000-0002-0113-0750)
- Jelmer R. Prins (ORCID: https://orcid.org/0000-0002-3984-2163)
- Jacob van den Born (ORCID: https://orcid.org/0000-0002-7883-5361)
- Marian Bulthuis
- M H de Jong-Schoots
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
Publication Details
- Journal
- Placenta
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1016/j.placenta.2025.09.001
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitair Medisch Centrum Groningen