Evaluating the effect of cannabidiol on sleep quality in patients with multiple sclerosis using 15 aggregated N-of-1 trials: A study protocol
This study aims to provide insight into the effects of a controlled CBD product on sleep quality in MS patients through an N-of-1 trial design. Given the substantial variability in sleep quality and the anticipated interindividual differences in CBD response, an N-of-1 design is considered a suitable methodological approach.
Authors
- Jop Mostert (ORCID: https://orcid.org/0000-0003-3640-9935)
- Renger F. Witkamp (ORCID: https://orcid.org/0000-0002-7935-8261)
- A.C.B. van Orten-Luiten (ORCID: https://orcid.org/0000-0002-5375-4004)
- Angelique Pijpers
- Sebastiaan Overeem (ORCID: https://orcid.org/0000-0002-6445-9836)
- Bo Anne Daniëlla Frederique Saals
- Lonneke M. van der Meijden-Erkelens
- Heleen A. Kuijper-Tissot van Patot
Institutions
- Wageningen University & Research (NL)
Publication Details
- Journal
- Contemporary Clinical Trials
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1016/j.cct.2025.108071
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00