The Versatility of Nickel: Advances in C–S Bond Formation

Abstract Nickel-catalyzed carbon–sulfur (C–S) bond formation is a key process in organic synthesis, being widely applied in pharmaceuticals, agrochemicals, and materials science. This account summarizes recent advances in Ni-catalyzed C–S bond construction, covering key factors such as ligand choice, solvent, and temperature, which affect yield and selectivity. Case studies illustrate the scope of the methods in producing complex molecules. Remaining challenges include broadening the substrate scope and enhancing the selectivity for the formation of asymmetric C–S bonds. This account concludes with future directions, emphasizing the need for more efficient catalysts to expand the role of nickel in synthetic chemistry.