Mentalization and Emotional-Cognitive Rigidity as predictors of esketamine's effects on Treatment-Resistant Depression: Findings from a prospective observational study
These findings highlight the importance of a personalized treatment approach in TRD. Esketamine may be particularly beneficial in reducing cognitive rigidity, improving mentalization, and breaking the cognitive inflexibility that contributes to sustained negative depressive thinking patterns. Further research is needed to refine patient stratification and optimize treatment strategies for individuals with TRD.
Authors
- Natascia Brondino (ORCID: https://orcid.org/0000-0002-3128-1592)
- Ranieri Domenico Cornaggia
- F. Mazzoni (ORCID: https://orcid.org/0009-0009-6684-7689)
- Matteo Marcatili (ORCID: https://orcid.org/0000-0002-1436-1961)
- Massimo Clerici (ORCID: https://orcid.org/0000-0001-8769-6474)
- Vassilis Martiadis (ORCID: https://orcid.org/0000-0002-3344-1000)
- F.L. Motta (ORCID: https://orcid.org/0000-0003-1249-4397)
- Tiziano Prodi (ORCID: https://orcid.org/0009-0001-8528-0480)
- Barbara Tarantino (ORCID: https://orcid.org/0000-0001-6384-2561)
- Bernardo Maria Dell’Osso (ORCID: https://orcid.org/0000-0001-9370-5365)
- Giovanni Martinotti (ORCID: https://orcid.org/0000-0002-7292-2341)
- Pierluigi Politi (ORCID: https://orcid.org/0000-0002-4602-2032)
- Miriam Olivola
- A. Guffanti
Institutions
- University of Pavia (IT)
- University of Chieti-Pescara (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1016/j.jad.2025.120231
- Citations
- 5
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 6.97