Perturbation of the ovine placental transcriptome occurs at sub-therapeutic exposures to antenatal steroid therapy
Placental transcriptomic disruption persisted at and below the ANS exposure necessary for lung maturation. These findings suggest placental involvement in both impaired fetal growth and steroid clearance and underscore the need to optimize ANS dosing.
Authors
- Yuya Saito (ORCID: https://orcid.org/0000-0002-4033-1424)
- Sebastián E. Illanes (ORCID: https://orcid.org/0000-0001-5433-9315)
- Sean W.D. Carter
- Yuki Takahashi (ORCID: https://orcid.org/0000-0002-6711-8295)
- Y. Kumagai
- Erin L. Fee (ORCID: https://orcid.org/0000-0003-1240-8006)
- Hunna J. Watson (ORCID: https://orcid.org/0000-0001-8405-381X)
- Martina A. Clarke (ORCID: https://orcid.org/0000-0002-4905-4566)
- Masatoshi Saito (ORCID: https://orcid.org/0000-0001-8122-6623)
- John P. Newnham (ORCID: https://orcid.org/0000-0001-9983-7457)
- Haruo Usuda (ORCID: https://orcid.org/0000-0002-9334-8086)
- Tsukasa Takahashi (ORCID: https://orcid.org/0000-0002-5567-4091)
- Mahesh Choolani (ORCID: https://orcid.org/0000-0001-8336-0973)
- Hideyuki Ikeda (ORCID: https://orcid.org/0009-0005-0707-6125)
- Demelza J. Ireland (ORCID: https://orcid.org/0000-0002-8763-3542)
- Matthew W. Kemp (ORCID: https://orcid.org/0000-0002-0869-1710)
- Binny Priya Sesurajan
- Alan Jobe
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- National University of Singapore (SG)
- The University of Western Australia (AU)
- Universidad de Los Andes, Chile (CL)
- Tohoku University Hospital (JP)
- National University Hospital (SG)
- Pathwest Laboratory Medicine (AU)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Placenta
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1016/j.placenta.2025.09.002
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Channel 7 Telethon Trust
- Women and Infants Research Foundation
- Stan Perron Charitable Foundation