Add-on therapies to levodopa improve pain modulation in Parkinson's disease with motor fluctuations: A prospective cohort study
Pain processing is altered in pwPD, independently of subjective pain complaints. MAO-B inhibitors, particularly safinamide and rasagiline, appear to restore pain thresholds and improve QOL, supporting their role in managing pain in PD.
Authors
- Nicolò Baldini
- Maria Gabriella Ceravolo (ORCID: https://orcid.org/0000-0002-2694-4638)
- Matteo Benedetti
- Elisa Andrenelli (ORCID: https://orcid.org/0000-0001-7982-9871)
- Marianna Capecci (ORCID: https://orcid.org/0000-0002-1472-606X)
- Filippo Augusto Barbini
- Jacopo Brambatti
Institutions
- Marche Polytechnic University (IT)
Publication Details
- Journal
- Parkinsonism & Related Disorders
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1016/j.parkreldis.2025.108019
- Citations
- 1
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39