Lipolyse Enzyms Levels in Patients with Obstructive Sleep Apnea Syndrome; Especially Perilipin-1

Introduction: Since obesity is an important risk factor in obstructive sleep apnea syndrome (OSAS), it will be important to determine the relationship between intracellular and intravascular lipolysis enzymes and OSAS. In this study we investigated the levels of lipolysis enzymes Perilipin-1 (Plin-1), adipose triglyceride lipase (ATGL), hormon sensitive lipase (HSL) and lipoprotein lipase (LPL) in patients with OSAS and the relationship between these enzymes and OSAS. Material method: 51 OSAS patients with obstructive sleep apnea syndrome and 25 volunteers diagnosed with simple snoring as a control group were included in the study. Polysomnographic evaluation, age, gender, and body mass index of each participant were recorded. Blood was taken from the participants on the same day to analyze enzymes. Results: Between the OSAS group (n:51) and the control group (n:25), age (mean: 45.3±10 vs 40.9±9.1, p value: 0.065), gender (female/male in the patient and control group, respectively: 5/46, 3/22, p value: 0.76) and BMI (min-max 23.3-40.1 vs 24-44.1, p value: 0.21, respectively) were similar. For ATGL, HSL, LPL, no significant difference was detected between the groups (median values: 65.9 vs 68.3, 7.30 vs 7.33, 484.2 vs 485.3, p values: 0.33, 0.69, 0.33, respectively). Plin-1 level was found to be significantly higher in the OSAS group (median value: 5.34 vs 4.87 ng/ml, p:0.038). It was determined that Plin-1 had a positive correlation with WASO (wake after sleep onset) and a negative correlation with total sleep time (p value: 0.003, 0.006, r value: 0.41, -0.38, respectively). In the linear regression analysis performed for the OSAS group, WASO was detected as a risk factor for Plin-1 elevation (p: 0.003, B: 0.012). Conclusion: We found that Plin-1 levels increased secondary to sleep disruptions in patients with OSAS, independent of obesity.