Amide-Directed C–H Acetoxylation of Cubanes
In this study, a palladium-catalyzed, amide-directed C-H acetoxylation of cubanes has been developed. The ortho positions of the amide directing group on cubanes were selectively acetoxylated without any stoichiometric strong bases. The number (1-3) of acetoxy groups introduced was determined by the amount of PhI(OAc)<sub>2</sub> used. Substitution at the C4 position of cubane dramatically affected the outcome of the acetoxylation reaction.
Authors
- Shota Nagasawa (ORCID: https://orcid.org/0000-0002-9207-4423)
- Yoshiharu Iwabuchi (ORCID: https://orcid.org/0000-0002-0679-939X)
Institutions
- Tohoku University (JP)
Publication Details
- Journal
- Chemical and Pharmaceutical Bulletin
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1248/cpb.c25-00449
- Citations
- 1
- Primary Topic
- Oxidative Organic Chemistry Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Japan Agency for Medical Research and Development
- Tokyo Biochemical Research Foundation
- Teijin Pharma
- Japan Society for the Promotion of Science