Sesquiterpenoids and monoterpenoids from the aerial parts of Sarcandra glabra (Thunb.) Nakai

Continual phytochemical investigation on the aerial parts of Sarcandra glabra (Thunb.) Nakai afforded fifteen compounds ( 1 – 15 ), comprising twelve sesquiterpenoids ( 1 – 12 ) and three monoterpenoids ( 13 – 15 ). The structures of these compounds were assigned by means of spectroscopic analysis, including 1D/2D NMR, HRESIMS, ECD calculations, and single-crystal X-ray diffractions. Compound 1 was a previously undescribed cadinane-type sesquiterpene, while compounds 4 , 5 , 9 , and 12 – 15 were isolated from S. glabra for the first time. Moreover, the chemotaxonomic significance of these constituents was also discussed. • Fifteen compounds were obtained from aerial parts of Sarcandra glabra. • Compound 1 was a previously undescribed cadinane-type sesquiterpene. • Compounds 4 , 5 , 9 , and 12 – 15 were isolated from S. glabra for the first time. • The chemotaxonomic significance of the isolated compounds was summarized.