Synthesis of phenazine-1,6-diyldimethanol, a natural product from Brevibacteria
A concise total synthesis of the C2-symmetric marine alkaloid, phenazine-1,6-diyldimethanol, is reported. X-ray crystal structures for three phenazine derivatives are presented, and a simple and general NMR-based method for distinguishing 1,6- from 1,9-disubstituted phenazines is described. • 3-step total synthesis. • Confirmation of reported structure. • A simple NMR-based method for determining phenazine regiochemistry.
Authors
- Ruoming Tian (ORCID: https://orcid.org/0000-0002-6832-5042)
- M.M. Bhadbhade
- Luke Hunter (ORCID: https://orcid.org/0000-0002-8678-3602)
- Giancarlo Pascali (ORCID: https://orcid.org/0000-0001-7919-8416)
- Ramsha Iftikhar (ORCID: https://orcid.org/0000-0002-6575-110X)
- Roger W. Read
Institutions
- Australian Nuclear Science and Technology Organisation (AU)
- UNSW Sydney (AU)
Publication Details
- Journal
- Tetrahedron Letters
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1016/j.tetlet.2025.155802
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00