Case-Control Study for 23 Cancer Types With Functional Analysis of <i>CHEK2</i> : Risk Estimation and Clinical Recommendations in East Asia
<i>CHEK2</i> gDVs were associated with female breast and prostate cancer risks in East Asia. The necessity of additional systematic clinical management for all <i>CHEK2</i> gDV carriers should be carefully discussed, and standard cancer screening is recommended unless no other clinical features suggestive of cancer predisposition are noted in East Asia.
Authors
- Yukihide Momozawa (ORCID: https://orcid.org/0000-0001-5638-3504)
- Zdeněk Kleibl (ORCID: https://orcid.org/0000-0003-2050-9667)
- Yoshiaki Usui (ORCID: https://orcid.org/0000-0001-6180-0704)
- Todd A. Johnson (ORCID: https://orcid.org/0000-0003-3377-6692)
- Kouya Shiraishi (ORCID: https://orcid.org/0000-0002-5821-7400)
- Takashi Kohno (ORCID: https://orcid.org/0000-0002-5371-706X)
- Yoichiro Kamatani (ORCID: https://orcid.org/0000-0001-8748-5597)
- Petra Kleiblová (ORCID: https://orcid.org/0000-0002-4806-9854)
- Kokichi Sugano (ORCID: https://orcid.org/0000-0001-6729-366X)
- Libor Macůrek (ORCID: https://orcid.org/0000-0002-0987-1238)
- Lenka Stolařová (ORCID: https://orcid.org/0000-0002-0047-1502)
- Yuri Takehara (ORCID: https://orcid.org/0000-0003-3285-4994)
- Koichi Matsuda (ORCID: https://orcid.org/0000-0001-7292-2686)
- Yoshinori Murakami (ORCID: https://orcid.org/0000-0002-2826-4396)
- Hidewaki Nakagawa (ORCID: https://orcid.org/0000-0003-1807-772X)
- Makoto Hirata (ORCID: https://orcid.org/0000-0002-9994-9958)
- Teruhiko Yoshida (ORCID: https://orcid.org/0000-0003-1607-3899)
- Yusuke Iwasaki
- Amanda B. Spurdle (ORCID: https://orcid.org/0000-0003-1337-7897)
- Mikiko Endo
Institutions
- Charles University (CZ)
- QIMR Berghofer Medical Research Institute (AU)
- Sasaki Institute (JP)
- Czech Academy of Sciences, Institute of Molecular Genetics (CZ)
- National Cancer Center Hospital East (JP)
- RIKEN Center for Integrative Medical Sciences (JP)
- General University Hospital in Prague (CZ)
- The University of Tokyo (JP)
- Nippon Medical School (JP)
- Yokohama City University (JP)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1200/po-24-00945
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00