Open-Label, Phase II Trial of Extracellular Regulated Kinase Inhibition Alone and in Combination With Autophagy Inhibition in Patients With Metastatic Pancreatic Cancer
LY3214996 alone or in combination with HCQ did not result in clinical activity in patients with metastatic PDAC.
Authors
- Junning Wang (ORCID: https://orcid.org/0000-0002-5559-9343)
- Kimberly J. Perez (ORCID: https://orcid.org/0000-0002-5745-2994)
- Matthew B.B. Yurgelun (ORCID: https://orcid.org/0000-0002-6184-9273)
- Anuj Patel (ORCID: https://orcid.org/0000-0002-7045-6957)
- R. Mayer (ORCID: https://orcid.org/0000-0002-0484-2876)
- James M. Cleary (ORCID: https://orcid.org/0000-0001-7213-3951)
- Peter D. Whooley
- Mary Linton B. Peters (ORCID: https://orcid.org/0000-0003-0905-7583)
- Rishi Surana (ORCID: https://orcid.org/0000-0002-8471-9236)
- Hannah L. Williams (ORCID: https://orcid.org/0000-0003-0434-3900)
- Colin D. Weekes (ORCID: https://orcid.org/0000-0001-6287-4334)
- Hui Zheng (ORCID: https://orcid.org/0000-0001-6725-1910)
- Srivatsan Raghavan (ORCID: https://orcid.org/0000-0002-5374-9918)
- Lauren K. Brais (ORCID: https://orcid.org/0000-0003-1069-0407)
- Micaela Morgado (ORCID: https://orcid.org/0000-0002-0390-5812)
- Neetu Saxena (ORCID: https://orcid.org/0000-0002-8585-2397)
- Aparna R. Parikh (ORCID: https://orcid.org/0000-0002-5245-7841)
- Christopher N. Graham (ORCID: https://orcid.org/0000-0001-8165-7095)
- Harshabad Singh (ORCID: https://orcid.org/0000-0001-6295-2013)
- Brandon M. Huffman (ORCID: https://orcid.org/0000-0002-0768-3145)
- Douglas A. Rubinson (ORCID: https://orcid.org/0000-0002-5337-5231)
- Thomas A. Abrams (ORCID: https://orcid.org/0000-0003-3101-1573)
- Emma Coleman
- Brian M. Wolpin (ORCID: https://orcid.org/0000-0002-0455-1032)
- Lee M. Ritterband (ORCID: https://orcid.org/0000-0001-7624-5213)
- Nadine J. McCleary (ORCID: https://orcid.org/0000-0003-2377-8301)
- Jonathan Andrew Nowak (ORCID: https://orcid.org/0000-0002-0943-7407)
- Andrea C. Enzinger (ORCID: https://orcid.org/0000-0001-7502-8081)
- Ashwin Somasundaram (ORCID: https://orcid.org/0000-0003-3167-406X)
- Channing J. Der (ORCID: https://orcid.org/0000-0002-7751-2747)
- Bruno Bockorny (ORCID: https://orcid.org/0000-0002-9162-1560)
- Andrea J. Bullock (ORCID: https://orcid.org/0000-0001-7143-0225)
- Leah H. Biller (ORCID: https://orcid.org/0000-0001-7386-7121)
- Joseph Douglas Mancias (ORCID: https://orcid.org/0000-0002-0692-3717)
- Kimmie Ng (ORCID: https://orcid.org/0000-0003-0631-1494)
- Kirsten L. Bryant (ORCID: https://orcid.org/0000-0003-4026-0942)
- Andrew J. Aguirre (ORCID: https://orcid.org/0000-0002-0701-6203)
- Jessica A. Zerillo (ORCID: https://orcid.org/0000-0001-9103-4473)
- Hanna K. Sanoff (ORCID: https://orcid.org/0000-0001-8679-4486)
- Jeffrey William Clark (ORCID: https://orcid.org/0000-0001-9524-3600)
- Peter C. Enzinger
- Sarah Slater
- Alexandra Bird (ORCID: https://orcid.org/0009-0007-0749-0873)
- Mark Sawin
Institutions
- University of North Carolina at Chapel Hill (US)
- Brigham and Women's Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Beth Israel Deaconess Hospital (US)
- Massachusetts General Hospital (US)
- Dana-Farber Cancer Institute (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1200/po-25-00332
- Citations
- 1
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.05