Open-Label, Phase II Trial of Extracellular Regulated Kinase Inhibition Alone and in Combination With Autophagy Inhibition in Patients With Metastatic Pancreatic Cancer

LY3214996 alone or in combination with HCQ did not result in clinical activity in patients with metastatic PDAC.

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Publication Details

Journal
JCO Precision Oncology
Published
2025-09-01
DOI
https://doi.org/10.1200/po-25-00332
Citations
1
Primary Topic
Pancreatic and Hepatic Oncology Research
Type
article
Field-Weighted Citation Impact
1.05
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article

Open-Label, Phase II Trial of Extracellular Regulated Kinase Inhibition Alone and in Combination With Autophagy Inhibition in Patients With Metastatic Pancreatic Cancer

Junning Wang, Kimberly J. Perez, Matthew B.B. Yurgelun, Anuj Patel et al.
1 citations
JCO Precision Oncology
Pancreatic and Hepatic Oncology Research
1.05
article

Open-Label, Phase II Trial of Extracellular Regulated Kinase Inhibition Alone and in Combination With Autophagy Inhibition in Patients With Metastatic Pancreatic Cancer

Junning Wang, Kimberly J. Perez, Matthew B.B. Yurgelun, Anuj Patel, R. Mayer, James M. Cleary, Peter D. Whooley, Mary Linton B. Peters, Rishi Surana, Hannah L. Williams, Colin D. Weekes, Hui Zheng, Srivatsan Raghavan, Lauren K. Brais, Micaela Morgado, Neetu Saxena, Aparna R. Parikh, Christopher N. Graham, Harshabad Singh, Brandon M. Huffman, Douglas A. Rubinson, Thomas A. Abrams, Emma Coleman, Brian M. Wolpin, Lee M. Ritterband, Nadine J. McCleary, Jonathan Andrew Nowak, Andrea C. Enzinger, Ashwin Somasundaram, Channing J. Der, Bruno Bockorny, Andrea J. Bullock, Leah H. Biller, Joseph Douglas Mancias, Kimmie Ng, Kirsten L. Bryant, Andrew J. Aguirre, Jessica A. Zerillo, Hanna K. Sanoff, Jeffrey William Clark, Peter C. Enzinger, Sarah Slater, Alexandra Bird, Mark Sawin
article en
1 citations

Abstract

LY3214996 alone or in combination with HCQ did not result in clinical activity in patients with metastatic PDAC.

JCO Precision OncologyVol. 9(9)
University of North Carolina at Chapel Hill (US), Brigham and Women's Hospital (US), Beth Israel Deaconess Medical Center (US), Harvard University (US), Beth Israel Deaconess Hospital (US), Massachusetts General Hospital (US), Dana-Farber Cancer Institute (US)
Openalex Percentile: Top 18%
Pancreatic and Hepatic Oncology Research
1.05
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