Lipid metabolism of clear cell renal cell carcinoma predicts survival and affects intratumoral CD8 T cells
Our study describes a robust, prognostic clustering of lipid gene expression that is both ccRCC-specific and independent of major parameters such as tumor size or aggressiveness. Furthermore, we propose that oleate accumulation in the RCC lipidome affects intratumoral CD8 T cell infiltration and function.
Authors
- Peter J. Siska (ORCID: https://orcid.org/0000-0002-1521-6213)
- Rainer Spang (ORCID: https://orcid.org/0000-0002-1326-4297)
- Marina Kreutz (ORCID: https://orcid.org/0000-0001-8762-9861)
- Katharina M. Freitag
- Marcus Höring (ORCID: https://orcid.org/0000-0002-3651-392X)
- Luisa Symeou
- Simon Engelmann (ORCID: https://orcid.org/0000-0003-3810-3307)
- Sebastian Kaelble
- Gerhard Liebisch (ORCID: https://orcid.org/0000-0003-4886-0811)
- Roman Mayr (ORCID: https://orcid.org/0000-0003-1796-3260)
- Florian Weber (ORCID: https://orcid.org/0000-0001-7480-8828)
- Renate Pichler (ORCID: https://orcid.org/0000-0001-5286-9048)
- Katja Dettmer (ORCID: https://orcid.org/0000-0001-7337-2380)
- Peter Josef Oefner (ORCID: https://orcid.org/0000-0002-1499-3977)
- Jakob Simeth (ORCID: https://orcid.org/0000-0002-7832-2582)
- Wolfgang Herr
- Maximilian Burger (ORCID: https://orcid.org/0009-0005-5013-9435)
- K Wagner
Institutions
- Innsbruck Medical University (AT)
- Universität Innsbruck (AT)
- University Hospital Regensburg (DE)
- University of Regensburg (DE)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1016/j.tranon.2025.102513
- Citations
- 3
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.81