Development of a compound herbal formulation (HBK) with antitumor and antioxidant functions for cancer adjuvant therapy
This study provides a comprehensive evaluation of a TCM-based multi-herb formulation for its immunomodulatory and antioxidant effects in lung cancer. HBK significantly enhanced anti-tumor immunity, increased antioxidant enzyme and cytokine activity, and remodeled the tumor microenvironment. Notably, these effects were mediated through inhibition of the TLR3/NF-κB signaling pathway. While individual herbal components have previously been linked to this pathway, our study is the first to demonstrate that a TCM-based multi-herb formula can modulate tumor immunity via TLR3/NF-κB inhibition in vivo.
Authors
- Lu‐Hai Wang (ORCID: https://orcid.org/0000-0003-0050-8560)
- Chao‐Jung Chen (ORCID: https://orcid.org/0000-0003-3834-9243)
- Hsuan-Chia Chang
- Ya‐Chih Huang (ORCID: https://orcid.org/0000-0001-9990-7494)
- Shijie Huang (ORCID: https://orcid.org/0000-0002-9508-0458)
- Huang‐Yu Yang (ORCID: https://orcid.org/0000-0001-6826-9717)
- Hsiang‐Cheng Chi (ORCID: https://orcid.org/0000-0001-5691-2453)
- Yu‐Ning Lin (ORCID: https://orcid.org/0000-0002-1960-9057)
- Chung‐Ying Tsai (ORCID: https://orcid.org/0000-0002-1444-5647)
Institutions
- Chang Gung University (TW)
- China Medical University (TW)
- Chang Gung Memorial Hospital (TW)
- China Medical University Hospital (TW)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1016/j.phymed.2025.157212
- Citations
- 4
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Ministry of Education
- China Medical University