The Intervention Fragility Quotient: An Improved Metric for Assessing Robustness in Clinical Trials

The reproducibility crisis in biomedical research highlights the need for more reliable statistical tools beyond the p-value. Fragility metrics, such as the Fragility Index and Fragility Quotient, have been proposed to measure the robustness of clinic

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Published
2025-09-02
DOI
https://doi.org/10.22541/au.175683409.91019967/v1
Primary Topic
Health Systems, Economic Evaluations, Quality of Life
Type
article
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article

The Intervention Fragility Quotient: An Improved Metric for Assessing Robustness in Clinical Trials

Thomas F Heston
Health Systems, Economic Evaluations, Quality of Life
article

The Intervention Fragility Quotient: An Improved Metric for Assessing Robustness in Clinical Trials

Thomas F Heston
article en

Abstract

The reproducibility crisis in biomedical research highlights the need for more reliable statistical tools beyond the p-value. Fragility metrics, such as the Fragility Index and Fragility Quotient, have been proposed to measure the robustness of clinic

Washington State University Spokane (US)
Openalex Percentile: Top 69%
Health Systems, Economic Evaluations, Quality of Life
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The Intervention Fragility Quotient: An Improved Metric for Assessing Robustness in Clinical Trials — Thomas F Heston · (2025) | TGRS Research Map | TGRS