Lipidomic profiling of human bile distinguishes cholangiocarcinoma from benign bile duct diseases with high specificity and sensitivity: a prospective descriptive study
This study not only identified lipidomic alterations in CCA using bile samples but also established and validated a bile lipid classifier with high specificity and sensitivity for distinguishing between CCA and benign bile duct diseases. Our findings highlight the potential of bile lipid biomarkers for improving the differential diagnosis and risk assessment of CCA and preventing potential overintervention in patients with benign biliary disease.
Authors
- Xiaomian Li (ORCID: https://orcid.org/0000-0002-0938-9329)
- Yufeng Yuan (ORCID: https://orcid.org/0000-0003-3924-3803)
- Yuan Tao (ORCID: https://orcid.org/0000-0002-8311-0736)
- Ming-He Zhang
- Wei‐Hua Huang (ORCID: https://orcid.org/0000-0001-8951-075X)
- Weijie Ma (ORCID: https://orcid.org/0000-0002-0399-6005)
- Bo Liao (ORCID: https://orcid.org/0000-0001-9770-5565)
- Xiaoyu Pan (ORCID: https://orcid.org/0000-0002-0282-6047)
- Xi Chen (ORCID: https://orcid.org/0000-0003-0248-8161)
- Jinghua Li (ORCID: https://orcid.org/0000-0002-9051-0674)
- Ping Jiang (ORCID: https://orcid.org/0000-0002-2715-6860)
- Fusheng Liu (ORCID: https://orcid.org/0000-0003-1175-5209)
- Shikun Zhang (ORCID: https://orcid.org/0000-0003-4485-9063)
- Junyu Zhou (ORCID: https://orcid.org/0000-0001-9392-5296)
- Yingyi Liu (ORCID: https://orcid.org/0000-0002-7745-8445)
- Shan Guo
- Wei-Xian Fang
- Xu-Yun Yan
- Yi-Bo Chai
- Tiangen Wu (ORCID: https://orcid.org/0009-0005-3801-1009)
- Song-Mei Liu
Institutions
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Hubei University (CN)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1038/s41416-025-03144-9
- Citations
- 3
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- Wuhan University
- Zhongnan Hospital of Wuhan University