Molecular Evolution of DNA Topoisomerases: Mechanisms, Diversification, and Functional Adaptation

Topoisomerases are one of the essential enzymes that regulate DNA topology. They enable crucial processes such as replication, transcription and chromosomal segregation across bacteria, archaea and eukaryotes. This review traces their emergence from a

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Published
2025-09-02
DOI
https://doi.org/10.22541/au.175641394.44967088/v2
Primary Topic
Cancer therapeutics and mechanisms
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article
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article

Molecular Evolution of DNA Topoisomerases: Mechanisms, Diversification, and Functional Adaptation

Phoolwanti Rani, Daksh Daksh
Cancer therapeutics and mechanisms
article

Molecular Evolution of DNA Topoisomerases: Mechanisms, Diversification, and Functional Adaptation

Phoolwanti Rani, Daksh Daksh
article en

Abstract

Topoisomerases are one of the essential enzymes that regulate DNA topology. They enable crucial processes such as replication, transcription and chromosomal segregation across bacteria, archaea and eukaryotes. This review traces their emergence from a

National Institute of Science Education and Research (IN), University of California San Diego (US)
Openalex Percentile: Top 80%
Cancer therapeutics and mechanisms
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Molecular Evolution of DNA Topoisomerases: Mechanisms, Diversification, and Functional Adaptation — Phoolwanti Rani, Daksh Daksh · (2025) | TGRS Research Map | TGRS