Investigating PRDM8 DNA Methylation in Peripheral Tissues in Borderline Personality Disorder: Association with Symptom Severity but Not Adverse Childhood Experiences
Our findings suggest that <i>PRDM8</i> DNAm might be associated with BPD and therapeutic intervention but not with ACE. Together with prior research, the results underscore the importance of future investigation of gene-environment interactions and the functional significance of <i>PRDM8</i> regulation in the pathophysiology of BPD.
Authors
- Sarah Pasche
- Susanne Edelmann (ORCID: https://orcid.org/0000-0002-6266-9303)
- Annika Bender
- Mirac Nur Musaoğlu (ORCID: https://orcid.org/0000-0002-7298-9909)
- Vanessa Nieratschker (ORCID: https://orcid.org/0000-0001-7884-4500)
- Laila Bertele
Institutions
- German Center for Infection Research (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Brain Sciences
- Published
- 2025-08-30
- DOI
- https://doi.org/10.3390/brainsci15090950
- Primary Topic
- Personality Disorders and Psychopathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft