Outcomes of patients aged 70 years or younger with aggressive ATL at core hospitals for ATL treatment in Tokyo

Adult T-cell leukemia-lymphoma (ATL) is one of the most intractable peripheral T-cell neoplasms caused by human T-cell leukemia virus type I (HTLV-1) infection. Recently, the incidence of HTLV-1 infection and ATL has increased in non-endemic metropolitan areas in Japan. This retrospective study evaluated the clinical features and outcomes of patients with aggressive ATL aged 70 years or younger treated at a core hospital in Tokyo between 2004 and 2016. The median follow-up was 124.4 months for survivors. Among the 71 patients, 46 (64.8%) underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT). The 3 year overall survival rate was 45.7% in allo-HSCT group versus 0% in non-allo-HSCT group. Patients who achieved complete/partial remission before allo-HSCT had a significantly better survival rate than those with stable/progressive disease (51.4% vs 27.3%). The 2 year cumulative incidence of relapse/progression and non-relapse mortality after allo-HSCT was 41.3% and 21.7%, respectively. In this study, a large percentage of patients underwent allo-HSCT and achieved favorable outcomes. As cases continue to rise in metropolitan areas, core hospitals will play a critical role in ATL treatment.

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Publication Details

Journal
International Journal of Hematology
Published
2025-09-02
DOI
https://doi.org/10.1007/s12185-025-04057-2
Primary Topic
T-cell and Retrovirus Studies
Type
article
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article

Outcomes of patients aged 70 years or younger with aggressive ATL at core hospitals for ATL treatment in Tokyo

Arinobu Tojo, Yoshihiro Inamoto, Kazuaki Yokoyama, Tomonari Takemura et al.
International Journal of Hematology
T-cell and Retrovirus Studies
article

Outcomes of patients aged 70 years or younger with aggressive ATL at core hospitals for ATL treatment in Tokyo

Arinobu Tojo, Yoshihiro Inamoto, Kazuaki Yokoyama, Tomonari Takemura, Satoshi Takahashi, Nobuhiro Ohno, Ayumu Ito, Junya Makiyama, Koji Jimbo, Shigeo Fuji, Yasuhito Nannya, Kaoru Uchimaru, Takashi Tanaka, Toyotaka Kawamata, Yoichi Imai, Takahiro Fukuda, Seiko Kato
article en

Abstract

Adult T-cell leukemia-lymphoma (ATL) is one of the most intractable peripheral T-cell neoplasms caused by human T-cell leukemia virus type I (HTLV-1) infection. Recently, the incidence of HTLV-1 infection and ATL has increased in non-endemic metropolitan areas in Japan. This retrospective study evaluated the clinical features and outcomes of patients with aggressive ATL aged 70 years or younger treated at a core hospital in Tokyo between 2004 and 2016. The median follow-up was 124.4 months for survivors. Among the 71 patients, 46 (64.8%) underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT). The 3 year overall survival rate was 45.7% in allo-HSCT group versus 0% in non-allo-HSCT group. Patients who achieved complete/partial remission before allo-HSCT had a significantly better survival rate than those with stable/progressive disease (51.4% vs 27.3%). The 2 year cumulative incidence of relapse/progression and non-relapse mortality after allo-HSCT was 41.3% and 21.7%, respectively. In this study, a large percentage of patients underwent allo-HSCT and achieved favorable outcomes. As cases continue to rise in metropolitan areas, core hospitals will play a critical role in ATL treatment.

International Journal of HematologyVol. 123(1)
Meiji Gakuin University (JP), Sasebo City General Hospital (JP), Tokyo Metropolitan Bokutoh Hospital (JP), Systems Biology Institute (JP), Yokohama Rosai Hospital (JP), Osaka International Cancer Institute (JP), Precision Research (United States) (US), Institute of Science Tokyo (JP), The University of Tokyo (JP), Dokkyo Medical University (JP)
Openalex Percentile: Top 75%
T-cell and Retrovirus Studies
DOIOpen Access PDFOpenAlex
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