Characterization of DMRT1 Variants for Testis Determination and Differentiation in Emu
These findings suggest that while molecular sex differentiation mechanisms are largely conserved between Palaeognathae and Neognathae, they differ in parts. In particular, early RSPO1 expression may initiate ovarian differentiation prior to testis determination by DMRT1. The presence of emu-specific DMRT1 variants further indicates possible species-specific mechanisms in testis development.
Authors
- Luisa Matiz-Céron (ORCID: https://orcid.org/0000-0001-8777-7047)
- Asato Kuroiwa (ORCID: https://orcid.org/0000-0002-3942-3372)
- Shusei Mizushima (ORCID: https://orcid.org/0000-0002-1176-1994)
- Yûki Kimura (ORCID: https://orcid.org/0000-0002-5054-8483)
- Miki Okuno (ORCID: https://orcid.org/0000-0002-6164-1878)
- Takehiko Itoh (ORCID: https://orcid.org/0000-0002-6113-557X)
- Shoichiro Mitsukawa
- Yutaka Suzuki (ORCID: https://orcid.org/0000-0003-4611-1809)
Institutions
- Hokkaido University of Science (JP)
- Kurume University (JP)
- Hokkaido University (JP)
- Life Science Institute (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Cytogenetic and Genome Research
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1159/000548251
- Primary Topic
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Type
- article
- Field-Weighted Citation Impact
- 0.00