Immune-Related Comorbidities in Pediatric Familial Mediterranean Fever: A Hidden Burden beyond Autoinflammation

A notable subset of pediatric familial Mediterranean fever patients demonstrates immune dysregulation extending beyond innate autoinflammation. These findings underscore the importance of immunologic assessment in patients with atypical features or inadequate response to colchicine. Early identification and appropriate immunomodulatory interventions may improve clinical outcomes in this distinct subgroup.