Limbal stem cell deficiency secondary to vitrectomy in the context of an autoimmune polyendocrine syndrome type
We describe a case of iatrogenic limbal stem cell insufficiency related to vitrectomy in a patient with autoimmune polyendocrine syndrome, a risk factor for this presentation. We propose that surgical trauma near the limbus and damage to the corneal sub-basal nerve plexus during vitrectomy may result in the development of limbal stem cell deficiency in a predisposed eye, as postulated in this patient with an APS.
Authors
- A. March (ORCID: https://orcid.org/0000-0001-8611-0312)
- Jordan J. Huang (ORCID: https://orcid.org/0000-0002-3779-5682)
- Francesc March de Ribot (ORCID: https://orcid.org/0000-0002-9438-4740)
- Jaime D. Martinez (ORCID: https://orcid.org/0000-0001-8307-7465)
- Joshua M. Huang
- J. Pérez
Institutions
- University of Miami (US)
- University of Ottawa (CA)
- University of Alberta (CA)
- Universitat de Girona (ES)
- Ottawa Hospital (CA)
- Corporació Sanitària Parc Taulí (ES)
- Hospital de Sabadell (ES)
- Institute of Research and Innovation Parc Tauli (ES)
- University of Otago (NZ)
Publication Details
- Journal
- American Journal of Ophthalmology Case Reports
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1016/j.ajoc.2025.102421
- Primary Topic
- Adrenal Hormones and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00