Statistical Analysis Plan for a Randomized Controlled Trial of Intensive Blood Pressure Control on Cardiovascular Risk Reduction in Patients with Atrial Fibrillation
A predefined SAP was established for the CRAFT trial to ensure a transparent and verifiable analysis. The SAP was finalized prospectively, independent of treatment assignment, with the goal of preserving internal validity and minimizing analytical bias.
Authors
- Craig S. Anderson (ORCID: https://orcid.org/0000-0002-7248-4863)
- Laurent Billot (ORCID: https://orcid.org/0000-0002-4975-9793)
- Anthony Rodgers (ORCID: https://orcid.org/0000-0003-1282-1896)
- Chao Jiang (ORCID: https://orcid.org/0000-0003-1138-7960)
- Xin Du (ORCID: https://orcid.org/0000-0003-3960-5317)
- Xiaolei Lin (ORCID: https://orcid.org/0000-0003-2463-1272)
- Bruce Charles Neal (ORCID: https://orcid.org/0000-0002-0490-7465)
- Anushka Patel (ORCID: https://orcid.org/0000-0003-3825-4092)
- Hisatomi Arima (ORCID: https://orcid.org/0000-0002-2064-2014)
- Zhiyan Wang (ORCID: https://orcid.org/0000-0002-1404-2696)
- Graham S. Hillis (ORCID: https://orcid.org/0000-0003-2417-4673)
- Qiang Li (ORCID: https://orcid.org/0000-0002-4384-8226)
- Changsheng Ma (ORCID: https://orcid.org/0000-0002-3612-7367)
- Jianzeng Dong (ORCID: https://orcid.org/0000-0002-3847-6069)
- Xia Wang (ORCID: https://orcid.org/0000-0002-3769-1293)
Institutions
- Capital Medical University (CN)
- Fudan University (CN)
- National Heart Foundation of Australia (AU)
- Royal Prince Alfred Hospital (AU)
- Royal Perth Hospital (AU)
- UNSW Sydney (AU)
- Fukuoka University (JP)
- National Clinical Research Center for Digestive Diseases (CN)
- The George Institute for Global Health (AU)
- Beijing Anzhen Hospital (CN)
- China National Health Development Research Center (CN)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
- Imperial College London (GB)
Publication Details
- Journal
- Cerebrovascular Diseases
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1159/000548288
- Primary Topic
- Health Systems, Economic Evaluations, Quality of Life
- Type
- article
- Field-Weighted Citation Impact
- 0.00