Bioactive Cyclodepsipeptides from Cocultured Mangrove-Derived <i>Aspergillus</i> sp. and <i>Penicillium</i> sp.
Three new arthrichitin derivatives I-K (<b>1</b>-<b>3</b>) and three known congeners (<b>4</b>-<b>6</b>) were isolated from a coculture of mangrove-derived fungi <i>Aspergillus</i> sp. and <i>Penicillium</i> sp. using <sup>1</sup>H NMR-guided fractionation. Their structures were determined by comprehensive spectroscopic analysis (1D/2D NMR, HRESIMS, ESI-MS/MS), Marfey's analysis, DP4+ probability, and experimental/computed ECD comparison. All compounds were evaluated for antibacterial effects and cytotoxicity. Notably, compounds <b>1</b> and <b>5</b> showed weak cytotoxicity against MHCC-97H cells (IC<sub>50</sub> = 20.1 ± 0.9 and 25.8 ± 0.4 μM, respectively). Compound <b>4</b> exhibited potent anti-BPH activity (IC<sub>50</sub> = 0.36 ± 0.02 μM).
Authors
- Guang-Ping Cao
- Xin-Jian Qu (ORCID: https://orcid.org/0009-0004-4838-3271)
- Meng Bai (ORCID: https://orcid.org/0000-0002-1024-3458)
- Xiangxi Yi (ORCID: https://orcid.org/0000-0002-8251-8836)
- Chenghai Gao (ORCID: https://orcid.org/0000-0002-7524-8049)
- Yonghong Liu (ORCID: https://orcid.org/0000-0001-8327-3108)
- Yu Wang (ORCID: https://orcid.org/0000-0001-8697-2940)
Institutions
- Guangxi University (CN)
- Guangxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1021/acs.jnatprod.5c00752
- Citations
- 1
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Natural Science Foundation of Guangxi Zhuang Autonomous Region
- Guangxi Traditional Chinese Medical University
- Guangxi Key Research and Development Program