Correlation between DNA double strand breaks and cell death in peripheral blood lymphocytes from breast cancer patients
These findings support previous studies done in cancer patients showing a negative correlation between apoptosis and γ-H2AX. Overall, our results seem to indicate that individuals with less efficiency in removing damaged cells, probably due to genetic polymorphisms, presented more basal and residual levels of DNA damage.
Authors
- Mònica Pujol-Canadell (ORCID: https://orcid.org/0000-0002-7403-9683)
- Javier González-Viguera (ORCID: https://orcid.org/0000-0001-9750-4667)
- Joan Francesc Barquinero (ORCID: https://orcid.org/0000-0003-0084-5268)
- Marina Arangüena Peñacoba
- Ferrán Guedea (ORCID: https://orcid.org/0000-0001-8798-8696)
- Víctor González‐Rumayor (ORCID: https://orcid.org/0000-0002-3205-1502)
- Milica Stefanović (ORCID: https://orcid.org/0000-0001-9293-4385)
- Isabel Linares (ORCID: https://orcid.org/0000-0002-6205-3859)
- Nadina Erill (ORCID: https://orcid.org/0000-0003-3530-2669)
- Gemma Armengol (ORCID: https://orcid.org/0000-0003-2345-1106)
- Montse Ventura (ORCID: https://orcid.org/0000-0002-3366-8360)
- Juan S. López (ORCID: https://orcid.org/0000-0002-9384-7504)
- E. Martinez (ORCID: https://orcid.org/0000-0002-3463-5333)
- Hector Pérez (ORCID: https://orcid.org/0000-0002-9756-5088)
- Miquel Macià Garau (ORCID: https://orcid.org/0000-0002-7328-4767)
- Ángela Solana-Peña (ORCID: https://orcid.org/0000-0001-5275-5278)
Institutions
- Universitat Autònoma de Barcelona (ES)
- Ecorys (Netherlands) (NL)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Departament de Salut (ES)
- Institut Català d'Oncologia (ES)
- Madrid Health Service (ES)
- Duran i Reynals Hospital (ES)
Publication Details
- Journal
- International Journal of Radiation Biology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1080/09553002.2025.2548465
- Citations
- 1
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Ministerio de Ciencia e Innovación