AdpA, a Global Regulator of Hundreds of Genes, Including Those for Secondary Metabolism, in Streptomyces venezuelae
This study defines, for the first time, the direct AdpA regulon in <i>S. venezuelae</i> and establishes AdpA<sub>Sv</sub> as a central regulator of secondary metabolism. Our findings highlight <i>S. venezuelae</i> as a promising chassis strain for heterologous expression and suggest strategies for activating silent BGCs in other <i>Streptomyces</i> species.
Authors
- Małgorzata Płachetka
- Michał Tracz (ORCID: https://orcid.org/0000-0001-7510-5024)
- Marcin Wolański (ORCID: https://orcid.org/0000-0003-4714-0716)
- Agnieszka Strzałka (ORCID: https://orcid.org/0000-0002-7092-0609)
- Jolanta Zakrzewska-Czerwińska
- Volha A. Naumouskaya
- Diana Valietova
Institutions
- University of Wrocław (PL)
Publication Details
- Journal
- Antibiotics
- Published
- 2025-08-30
- DOI
- https://doi.org/10.3390/antibiotics14090878
- Citations
- 1
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Narodowym Centrum Nauki