Penetrating Triple-Layer Involvement: Scalp, Skull, and Dura Mater By Follicular Lymphoma –An Unusual Presentation Mimicking Traumatic Meningioma

The authors report an exceptionally rare case of follicular lymphoma (FL) with simultaneous penetration through the scalp, skull, and dura mater in a 31-year-old female presenting with a progressive scalp mass and a left frontal lesion. Initially misdiagnosed as a traumatic meningioma based on history and imaging (showing a dural-based mass with "dural tail sign" and subgaleal fluid), surgical resection revealed FL with atypical features: BCL2 negativity (suggesting potential aggressiveness), high Ki67 (50%), and diffuse growth invading the dura. This case underscores the importance of including lymphoma, even indolent FL, in the differential diagnosis of lesions spanning scalp, bone, and meninges, especially with atypical features or trauma history.

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Publication Details

Journal
Journal of Craniofacial Surgery
Published
2025-09-01
DOI
https://doi.org/10.1097/scs.0000000000011680
Primary Topic
Lymphoma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
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article

Penetrating Triple-Layer Involvement: Scalp, Skull, and Dura Mater By Follicular Lymphoma –An Unusual Presentation Mimicking Traumatic Meningioma

Baisheng Li, Yang Sun, Jianqiu Chen
Journal of Craniofacial Surgery
Lymphoma Diagnosis and Treatment
article

Penetrating Triple-Layer Involvement: Scalp, Skull, and Dura Mater By Follicular Lymphoma –An Unusual Presentation Mimicking Traumatic Meningioma

Baisheng Li, Yang Sun, Jianqiu Chen
article en

Abstract

The authors report an exceptionally rare case of follicular lymphoma (FL) with simultaneous penetration through the scalp, skull, and dura mater in a 31-year-old female presenting with a progressive scalp mass and a left frontal lesion. Initially misdiagnosed as a traumatic meningioma based on history and imaging (showing a dural-based mass with "dural tail sign" and subgaleal fluid), surgical resection revealed FL with atypical features: BCL2 negativity (suggesting potential aggressiveness), high Ki67 (50%), and diffuse growth invading the dura. This case underscores the importance of including lymphoma, even indolent FL, in the differential diagnosis of lesions spanning scalp, bone, and meninges, especially with atypical features or trauma history.

Journal of Craniofacial Surgery
Sun Yat-sen University (CN), Sixth Affiliated Hospital of Sun Yat-sen University (CN), South China University of Technology (CN)
Openalex Percentile: Top 67%
Lymphoma Diagnosis and Treatment
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