Exploring the Reliability of Detecting Drug–Drug Interactions that Increase the Risk of Gestational Diabetes in Adverse Event Reporting Systems
Statistical signals of DDIs between ADs and potential interacting drugs during pregnancy were identified but not pursued further after case reviews. Uncertainty around medication use and event timing affected the reliability of the outcomes. These findings highlight the need to validate signals using detailed report data and stress the importance of accurate medication reporting.
Authors
- Boukje C Raemaekers
- G. Niklas Norén (ORCID: https://orcid.org/0000-0002-4595-230X)
- Catharina C. M. Schuiling‐Veninga (ORCID: https://orcid.org/0000-0002-8527-2608)
- Eelko Hak (ORCID: https://orcid.org/0000-0003-0849-7210)
- Lovisa Sandberg (ORCID: https://orcid.org/0000-0001-6982-5244)
- Jim W. Barrett (ORCID: https://orcid.org/0000-0002-0151-0753)
- Robiyanto Robiyanto
- Eugène van Puijenbroek (ORCID: https://orcid.org/0000-0002-2236-1398)
Institutions
- Uppsala Monitoring Centre (SE)
- Tanjungpura University (ID)
- University of Groningen (NL)
- Netherlands Pharmacovigilance Centre Lareb (NL)
Publication Details
- Journal
- Drug Safety
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1007/s40264-025-01607-9
- Citations
- 2
- Primary Topic
- Pharmacovigilance and Adverse Drug Reactions
- Type
- article
- Field-Weighted Citation Impact
- 2.61