Assessing the impact of perfluoroalkyl substances on liver health: a comprehensive study using multi-donor human liver spheroids
Our findings suggest that PFAS disrupt liver metabolism and may promote pro-oncogenic signaling through compound- and sex-specific mechanisms. These insights enhance our understanding of PFAS hepatotoxicity and underscore the importance of considering sex as a biological variable in future toxicological and public health assessments.
Authors
- Matthew P. Salomon (ORCID: https://orcid.org/0000-0002-3935-5306)
- Lucy Golden‐Mason (ORCID: https://orcid.org/0000-0002-2087-4405)
- Veronica Wendy Setiawan (ORCID: https://orcid.org/0000-0001-9239-5692)
- Lida Chatzi (ORCID: https://orcid.org/0000-0002-3319-2438)
- Ana C. Maretti‐Mira (ORCID: https://orcid.org/0000-0002-6252-2811)
- Yufen Wang
- Chikako Matsuba
Institutions
- University of Southern California (US)
Publication Details
- Journal
- Environment International
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.envint.2025.109763
- Citations
- 5
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 4.30
Funders
- National Institutes of Health
- HORIZON EUROPE Framework Programme
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Environmental Health Sciences