Effect of depression on risks of Alzheimer’s disease and vascular dementia: A real-world longitudinal study
Our findings unveil a significant association between depression and all-cause dementia, Alzheimer's disease and vascular dementia. The unique temporal association suggests that depression may serve as both a risk factor and a prodromal symptom for Alzheimer's disease, and solely as a risk factor for vascular dementia.
Authors
- Weihao Shao (ORCID: https://orcid.org/0000-0003-0362-6474)
- Chi Hu
- Ruitai Shao (ORCID: https://orcid.org/0000-0003-1977-7445)
- Jiajuan Yang
- Enying Gong (ORCID: https://orcid.org/0000-0003-2203-0369)
- Zuolin Lu (ORCID: https://orcid.org/0000-0002-9651-6065)
- Maigeng Zhou (ORCID: https://orcid.org/0000-0002-1046-6803)
- Yueqing Wang (ORCID: https://orcid.org/0000-0002-3676-5123)
- Xiaoxia Wei (ORCID: https://orcid.org/0000-0002-7350-3464)
- He Xu (ORCID: https://orcid.org/0009-0003-3744-7340)
- Xunliang Tong
- Luzhao Feng
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Hubei Provincial Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Psychiatry Research
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1016/j.psychres.2025.116716
- Citations
- 4
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 5.88
Funders
- Chinese Academy of Medical Sciences