Dingxin recipe III ameliorates endothelial cell senescence in atherosclerosis by activating the FOXO3a/PINK1/Parkin axis
Our findings for the first time demonstrated that DXRIII effectively alleviates endothelial senescence and HFD-induced AS, possibly by activating FOXO3a and subsequently enhancing PINK1/Parkin-mediated mitophagy.
Authors
- Yuhua Jia (ORCID: https://orcid.org/0000-0001-6508-4418)
- Hua-Shan Zhao
- Zhaoyong Li (ORCID: https://orcid.org/0000-0002-1502-4027)
- Peikun He
- Xinghong Zhou (ORCID: https://orcid.org/0000-0002-8066-1188)
- Lifang Zhang (ORCID: https://orcid.org/0000-0001-8706-1970)
- Xiaoyu Liu (ORCID: https://orcid.org/0009-0004-3994-3265)
- Jin Yao (ORCID: https://orcid.org/0000-0001-7567-3769)
- Yi Zhu (ORCID: https://orcid.org/0000-0003-1372-4203)
- Yuyan Gu
- Yaxin Zhang
- Yuling Xu
- Saibo Cheng
Institutions
- Fujian Medical University (CN)
- Dongguan University of Technology (CN)
- Shenzhen Sixth People's Hospital (CN)
- Dongguan People’s Hospital (CN)
- TCM-Intigrated Cancer Center of Southern Medical University (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1016/j.jep.2025.120525
- Citations
- 3
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- Southern Medical University
- Basic and Applied Basic Research Foundation of Guangdong Province