Plasma metabolic landscape unveils key regulators of leukemia subtype progression
Our MR study provides a comprehensive evaluation of the metabolomic landscape of leukemia, identifying subtype-specific causal associations involving pathways such as energy metabolism, amino acid metabolism, lipid signaling, and redox homeostasis. These findings offer insights into potential plasma biomarkers and therapeutic targets, revealing distinct metabolic vulnerabilities that warrant further investigation for precision treatment strategies across leukemia subtypes.
Authors
- Cong Liang (ORCID: https://orcid.org/0000-0002-6312-2991)
- Hongman Xue
- Liuhua Liao
- Jiayu Lin (ORCID: https://orcid.org/0000-0002-9525-397X)
- Jiajie Chen (ORCID: https://orcid.org/0000-0002-6663-5813)
- Jia-Tong Dai
- Shiyao Song
- Zhi-Yong Ke
Institutions
- Sun Yat-sen University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Huizhou Central People's Hospital (CN)
Publication Details
- Journal
- Future Science OA
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1080/20565623.2025.2527015
- Citations
- 1
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 1.77