Constructing chimeric mouse islets to study alpha- and delta-cell influence on beta-cell feature
We developed an innovative and easy-to-use model to reconstruct chimeric islets containing different frequencies of alpha-, beta- and delta-cells. Through this approach, we provide new insights into the complex regulatory mechanisms governing the role of alpha and delta cells on beta-cell features within islets.
Authors
- Masaya Oshima (ORCID: https://orcid.org/0000-0002-9774-0931)
- Raphaël Scharfmann (ORCID: https://orcid.org/0000-0001-7619-337X)
- Latif Rachdi (ORCID: https://orcid.org/0000-0002-1089-2837)
- Alexis Fouque
- Florence Gbahou (ORCID: https://orcid.org/0000-0002-2795-378X)
- Over Cabrera
- Delphine Thibaut
- Nina Modé
- Romain Ducellier
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Eli Lilly (United States) (US)
- Institut Cochin (FR)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.molmet.2025.102245
- Citations
- 3
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- Eli Lilly and Company
- Agence Nationale de la Recherche
- HORIZON EUROPE Framework Programme