A modular, adaptable, and accessible implant kit for chronic electrophysiological recordings in rats

Electrophysiological implants enable exploration of the relationship between neuronal activity and behavior. These technologies evolve rapidly, with multiple iterations of recording systems developed and utilized. Chronic implants must address a litany of complications, including retention of high signal-to-noise ratio in probes and the ability to withstand excess force over the experimental period. To overcome these issues, we designed a chronic implant for rats. Our comprehensive protocol optimizes the entire implant process, from assembling and testing the probes (Neuropixels) to implantation. In addition to addressing the complications previously mentioned, our implant can vertically adjust probes with micron precision and is constructed using modular components, allowing it to be easily modified for various research contexts, electrophysiological recording systems, headstages, and probe types.

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Publication Details

Journal
Cell Reports Methods
Published
2025-09-01
DOI
https://doi.org/10.1016/j.crmeth.2025.101146
Primary Topic
Neuroscience and Neural Engineering
Type
article
Field-Weighted Citation Impact
0.00

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article

A modular, adaptable, and accessible implant kit for chronic electrophysiological recordings in rats

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Cell Reports Methods
Neuroscience and Neural Engineering
article

A modular, adaptable, and accessible implant kit for chronic electrophysiological recordings in rats

Serina A. Batson, Kenichiro Negishi, Travis M. Moschak, Lara I. Rakocevic, Alexis A. Salcido, Ki A. Goosens, Sabrina M. Drammis, Cory N. Heaton, Raquel J. Ibáñez Alcalá, Neftali F. Reyes, Atanu Giri, Alexander Friedman, Luis D. Davila, Dirk W. Beck, Andrea Y. Macias, Ricardo Sosa Jurado
article en

Abstract

Electrophysiological implants enable exploration of the relationship between neuronal activity and behavior. These technologies evolve rapidly, with multiple iterations of recording systems developed and utilized. Chronic implants must address a litany of complications, including retention of high signal-to-noise ratio in probes and the ability to withstand excess force over the experimental period. To overcome these issues, we designed a chronic implant for rats. Our comprehensive protocol optimizes the entire implant process, from assembling and testing the probes (Neuropixels) to implantation. In addition to addressing the complications previously mentioned, our implant can vertically adjust probes with micron precision and is constructed using modular components, allowing it to be easily modified for various research contexts, electrophysiological recording systems, headstages, and probe types.

Cell Reports MethodsVol. 5(9)
Allen Institute for Brain Science (US), National Institute on Drug Abuse (US), The University of Texas at El Paso (US), Massachusetts Institute of Technology (US), Icahn School of Medicine at Mount Sinai (US)
National Science Foundation, University of Texas at El Paso, National Institute on Drug Abuse
Openalex Percentile: Top 75%
Neuroscience and Neural Engineering
DOIOpen Access PDFOpenAlex
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