Clot twist – D-dimer analysis of healthy adults receiving heterologous or homologous booster COVID-19 vaccine after a single prime dose of Ad26.COV2.S in a phase II randomised open-label trial, BaSiS
Elevated D-dimer levels in asymptomatic, low-risk adults were unexpectedly common and not associated with thromboembolism. This supports the rationale of including D-dimer testing in conjunction with other coagulopathy markers, only if clinically indicated in both COVID-19 vaccine clinical trials and the general population.
Authors
- Nigel Garrett (ORCID: https://orcid.org/0000-0002-4530-234X)
- Glenda Gray (ORCID: https://orcid.org/0000-0003-4649-1477)
- Mrinmayee Dhar (ORCID: https://orcid.org/0000-0001-9353-4295)
- Penny L. Moore (ORCID: https://orcid.org/0000-0001-8719-4028)
- Faeezah Patel (ORCID: https://orcid.org/0000-0003-1503-2016)
- Helen Rees (ORCID: https://orcid.org/0000-0003-1442-6734)
- Barry Jacobson (ORCID: https://orcid.org/0000-0001-6981-3112)
- Jean Le Roux (ORCID: https://orcid.org/0009-0000-7229-3031)
- Alex Sigal (ORCID: https://orcid.org/0000-0001-8571-2004)
- Erica Lazarus (ORCID: https://orcid.org/0000-0002-4965-0624)
- Ahmadou Nana
- Shobna Sawry (ORCID: https://orcid.org/0000-0002-3845-4863)
- Lee Fairlie (ORCID: https://orcid.org/0000-0001-5327-1734)
- Katherine Gill (ORCID: https://orcid.org/0000-0002-3372-9506)
- Robert Kieser (ORCID: https://orcid.org/0000-0003-2736-2872)
Institutions
- National Health Laboratory Service (ZA)
- South African Medical Research Council (ZA)
- Desmond Tutu HIV Foundation (ZA)
- University of Cape Town (ZA)
- University of the Witwatersrand (ZA)
- Centre for the AIDS Programme of Research in South Africa (ZA)
- Max Planck Institute for Infection Biology (DE)
- Africa Health Research Institute (ZA)
- Perinatal HIV Research Unit (ZA)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- South African Medical Journal
- Published
- 2025-09-02
- DOI
- https://doi.org/10.7196/samj.2025.v115i8.3121
- Primary Topic
- Advanced Biosensing Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Janssen Pharmaceuticals