Feeding state-dependent neuropeptidergic modulation of reciprocally interconnected inhibitory neurons biases sensorimotor decisions in Drosophila
An animal's feeding state changes its behavioral priorities and thus influences even nonfeeding-related decisions. How the feeding state information is transmitted to nonfeeding-related circuits and what circuit mechanisms are involved in biasing nonfeeding-related decisions remain open questions. By combining calcium imaging, neuronal manipulations, behavioral analysis and computational modeling, we determined that the competition between different aversive responses to mechanical cues is biased by changes in the feeding state. We found that this effect is achieved by the differential modulation of two different types of reciprocally connected inhibitory neurons promoting opposing actions. This modulation results in a more frequent active type of response and, less frequently, a protective type of response if larvae are fed sugar than when they are fed a balanced diet. Information about the internal state is conveyed to inhibitory neurons through homologs of the vertebrate neuropeptide Y, which is known to be involved in regulating feeding behavior.
Authors
- Francesca Viscido (ORCID: https://orcid.org/0000-0001-5734-4435)
- Panagiotis Sakagiannis (ORCID: https://orcid.org/0000-0002-1033-5387)
- Alexandre Blanc (ORCID: https://orcid.org/0000-0001-9148-5223)
- Chloé Barré (ORCID: https://orcid.org/0000-0002-4551-8984)
- Martin Paul Nawrot (ORCID: https://orcid.org/0000-0003-4133-6419)
- François Laurent (ORCID: https://orcid.org/0000-0002-1615-6400)
- Sandra Autran
- Tihana Jovanic (ORCID: https://orcid.org/0000-0002-0525-8620)
- Éloïse de Tredern
- Jean‐Baptiste Masson (ORCID: https://orcid.org/0000-0002-5484-9056)
- Dylan Manceau
- Victoria Sus
- Perla Akiki
- A. Parameswaran
- Md Amit Hasan
Institutions
- Centre National de la Recherche Scientifique (FR)
- Institut national de recherche en sciences et technologies du numérique (FR)
- Institut Pasteur (FR)
- University of Cologne (DE)
- Université Paris Cité (FR)
- Université Paris-Saclay (FR)
- Institut des Neurosciences Paris-Saclay (FR)
Publication Details
- Journal
- Nature Communications
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1038/s41467-025-61805-y
- Citations
- 2
- Primary Topic
- Neurobiology and Insect Physiology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- National Science Foundation
- U.S. Department of Energy
- Deutsche Forschungsgemeinschaft
- Agence Nationale de la Recherche
- Bundesministerium für Bildung und Forschung
- Fondation pour la Recherche Médicale
- Fédération pour la Recherche sur le Cerveau
- Fondation des Treilles