Anti-Fibrotic and Regenerative Potential of Mesenchymal Stem Cell-Derived Exosomes in Cisplatin-Induced Kidney Injury
Cisplatin is a widely used chemotherapeutic agent with potent antitumor activity; however, its nephrotoxicity limits clinical use, affecting 30–40% of treated patients. This study aimed to investigate the effects of mesenchymal stem cell-derived exosomes on cisplatin-induced nephrotoxicity and fibrosis in rat kidney tissue. Rats were divided into Control, Cis, Exo, and Cis+Exo groups. Nephrotoxicity was induced by a single dose Cis. Exosomes were isolated using a commercial kit and characterized by nanoparticle tracking analysis. Histopathological evaluations were performed Hematoxylin&Eosin and Periodic Acid-Schiff. Fibrosis markers were assessed by immunohistochemistry. Statistical analyses were conducted using one-way ANOVA and Kruskal-Wallis tests with Bonferroni and Dunn’s post-hoc tests, considering p
Authors
- Zeynep Burçin Gönen (ORCID: https://orcid.org/0000-0003-2725-9330)
- Arzu Hanım YAY (ORCID: https://orcid.org/0000-0002-0541-8372)
- Kübra Tuğçe Kalkan (ORCID: https://orcid.org/0000-0001-7461-277X)
- Halime Tozak Yıldız
- Gözde Özge Önder (ORCID: https://orcid.org/0000-0002-0515-9286)
- Numan Baydilli (ORCID: https://orcid.org/0000-0003-1017-3653)
- Eda Köseoğlu (ORCID: https://orcid.org/0000-0002-0502-7814)
- Özge Cengiz Mat (ORCID: https://orcid.org/0000-0003-4638-6116)
Institutions
- Ahi Evran University (TR)
- Erciyes University (TR)
Publication Details
- Journal
- Uludağ Üniversitesi Tıp Fakültesi Dergisi
- Published
- 2025-08-28
- DOI
- https://doi.org/10.32708/uutfd.1691390
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81