A single-cell transcriptome atlas of pig skin reveals cellular heterogeneity from embryonic development to postnatal aging
This work delineates cellular dynamics underpinning skin homeostasis, uncovers the vital physiological functions of FBs and immune cells during skin development and aging, and validates the pig model for human cutaneous physiology research. The atlas serves as a pivotal resource for skin mechanistic and translational studies.
Authors
- Zhengli Chen (ORCID: https://orcid.org/0000-0002-9850-528X)
- Zhengyin Gong
- Rong Yuan (ORCID: https://orcid.org/0000-0001-9996-7331)
- Yanzhi Jiang
- Ting Zheng (ORCID: https://orcid.org/0009-0002-7518-3457)
- Yifei Wang (ORCID: https://orcid.org/0000-0002-9918-2865)
- Yujing Li (ORCID: https://orcid.org/0000-0002-4363-2484)
- Qin Zou (ORCID: https://orcid.org/0000-0001-7292-0680)
- Yu Zhang (ORCID: https://orcid.org/0000-0002-5592-111X)
Institutions
- BGI Group (China) (CN)
- Sichuan Agricultural University (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1186/s12915-025-02390-w
- Citations
- 2
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 1.61