Gut microbiota dysbiosis and systemic immune dysfunction in critical ill patients with multidrug-resistant bacterial colonization and infection
Overall, MDRO colonization and infection lead to gut dysbiosis and immune dysfunction, with microbiota-immune interactions playing a crucial role in disease progression, suggesting the gut microbiota as a potential diagnostic and therapeutic target for AMR.
Authors
- Zongxin Ling (ORCID: https://orcid.org/0000-0001-9662-099X)
- Ruilai Jiang
- Jingchen Zhang (ORCID: https://orcid.org/0000-0003-3132-916X)
- Xiaocui Xu (ORCID: https://orcid.org/0000-0003-2488-3664)
- Xia Liu (ORCID: https://orcid.org/0000-0002-0180-2166)
- Wenwen Ding (ORCID: https://orcid.org/0009-0000-3473-588X)
- Lingbin Wu
- Yongtao Gao (ORCID: https://orcid.org/0000-0002-9436-7393)
- Yiwen Cheng (ORCID: https://orcid.org/0000-0002-3904-1032)
- Zhangcheng Zhu
Institutions
- Nantong University (CN)
- Wenzhou Medical University (CN)
- First People's Hospital of Yuhang District (CN)
- Lishui City People's Hospital (CN)
- National Centre for Infectious Diseases (SG)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1186/s12967-025-07049-2
- Citations
- 7
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- National Natural Science Foundation of China
- State Key Laboratory for Diagnosis and Treatment of Infectious Diseases
- Fundamental Research Funds for the Central Universities
- National Key Transform Program
- Natural Science Foundation of Zhejiang Province