Identification of Potential Targets for EGFR-Regulated Nucleus Pulposus Degeneration Using Single-Cell RNA Sequencing and Machine Learning
This study reveals a significant degenerative process in NPC and indicates that EGFR may contribute to this degeneration by regulating JAK1, thereby identifying a potential therapeutic target for delaying IVDD.
Authors
- Weihua Xu (ORCID: https://orcid.org/0000-0002-2570-5897)
- Xiaoyao Peng (ORCID: https://orcid.org/0009-0002-9937-5242)
- Yuxiang Hu (ORCID: https://orcid.org/0000-0001-5641-0357)
- Fashuai Wu
- Yulong Wei (ORCID: https://orcid.org/0000-0003-3823-9984)
- Pengfei Zhang (ORCID: https://orcid.org/0000-0003-4437-8112)
- Yi Wang (ORCID: https://orcid.org/0000-0003-4060-5736)
- Yangyang Chen (ORCID: https://orcid.org/0000-0003-2505-1982)
Institutions
- Union Hospital (HK)
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.2147/jir.s530776
- Citations
- 1
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 1.05