Anti-Inflammatory Modified Fuzi Decoction Antagonizes Synovial TNF-α/TRAF2/NF-κB Signaling to Remedy Osteoarthritis
This study demonstrated that MFZD exerts anti-degenerative and anti-inflammatory potency against OA and revealed the TNF-α/TRAF2/NF-κB signaling related anti-inflammatory mechanism of MFZD for the first time, offering mechanistic insights into its potential in OA therapy.
Authors
- Letian Shan (ORCID: https://orcid.org/0000-0003-4926-0527)
- Wenting Xu (ORCID: https://orcid.org/0000-0001-9222-1473)
- Xiaotian Chen (ORCID: https://orcid.org/0000-0002-4350-962X)
- Qiang Yuan (ORCID: https://orcid.org/0000-0002-1450-7086)
- Li Zhou (ORCID: https://orcid.org/0000-0003-1083-0211)
- Huixin Chen (ORCID: https://orcid.org/0000-0002-5629-0487)
- Bo Yan
- Jiadan Ren
- Xiujuan Xiao
- Yue Wang (ORCID: https://orcid.org/0009-0002-4473-5167)
Institutions
- Zhejiang Chinese Medical University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-09-01
- DOI
- https://doi.org/10.2147/dddt.s481770
- Citations
- 1
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.67