Combination of Polydatin and Hawthorn Leave Flavonoids Ameliorate Atherosclerotic Plaque Vulnerability in ApoE−/− Mice by Regulating Ferroptosis via the Nrf2/HO-1/GPX4 Axis
PH combination reduced the instability of atherosclerotic lesions in ApoE<sup>-/-</sup> mice by modulating iron metabolism and lipid peroxidation through activation of the Nrf2/ HO-1/GPX4 axis.
Authors
- Lanqing Hu (ORCID: https://orcid.org/0000-0001-8795-1316)
- Longtao Liu
- Changxin Sun (ORCID: https://orcid.org/0000-0002-1264-7886)
- Xiaonan Zhang (ORCID: https://orcid.org/0000-0001-7664-4222)
- Xiaoya Li (ORCID: https://orcid.org/0000-0002-8550-8385)
- Min Wu (ORCID: https://orcid.org/0009-0002-9861-0204)
- Jiye Chen (ORCID: https://orcid.org/0000-0002-6908-8202)
- Yongfang Yuan
- Zeping Wang
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Beijing University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Xiyuan Hospital (CN)
- China Academy of Chinese Medical Sciences (CN)
- Guang’anmen Hospital (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.2147/jir.s530995
- Citations
- 2
- Primary Topic
- Medicinal Plant Pharmacodynamics Research
- Type
- article
- Field-Weighted Citation Impact
- 3.11