Plasma proteomics identifies molecular subtypes in sepsis
The identified plasma proteome subtypes provide insights into the immune response and disease mechanisms and allow conclusions on appropriate therapeutic measures, enabling predictive enrichment in clinical trials. Thus, they represent a step forward in the development of targeted therapies and personalized medicine for sepsis.
Authors
- Malte Bayer (ORCID: https://orcid.org/0000-0003-1060-8856)
- Thilo von Groote
- Thilo Bracht (ORCID: https://orcid.org/0000-0002-1194-6614)
- Ulrich Limper (ORCID: https://orcid.org/0000-0001-9927-4180)
- Stefan Ehrentraut (ORCID: https://orcid.org/0000-0001-5747-6737)
- Dietrich Henzler (ORCID: https://orcid.org/0000-0001-5511-6885)
- Matthias Unterberg (ORCID: https://orcid.org/0000-0002-1500-1984)
- Alexander Zarbock (ORCID: https://orcid.org/0000-0002-2124-1714)
- Tim Rahmel (ORCID: https://orcid.org/0000-0002-7039-6288)
- K Käppler
- Lars Palmowski
- Nina Babel (ORCID: https://orcid.org/0000-0003-3673-712X)
- Katrin Marcus (ORCID: https://orcid.org/0000-0002-3313-8845)
- Lars Bergmann (ORCID: https://orcid.org/0000-0002-8603-8549)
- Björn Koos (ORCID: https://orcid.org/0000-0002-0544-4124)
- Katharina Rump (ORCID: https://orcid.org/0000-0003-2220-519X)
- Michael Adamzik (ORCID: https://orcid.org/0000-0002-7188-4873)
- Barbara Sitek
- Stephanie Pfaender (ORCID: https://orcid.org/0000-0002-3957-5448)
- Karin Schork (ORCID: https://orcid.org/0000-0003-3756-4347)
- Hartmuth Nowak (ORCID: https://orcid.org/0000-0002-6509-1463)
- Dominik Ziehe
- Martin Eisenacher (ORCID: https://orcid.org/0000-0003-2687-7444)
- Martina Broecker‐Preuss (ORCID: https://orcid.org/0000-0003-4537-0964)
- Franziska Grell
Institutions
- Leibniz Institute of Virology (LIV) (DE)
- Witten/Herdecke University (DE)
- University Hospital Bonn (DE)
- University Hospitals of the Ruhr-University of Bochum (DE)
- Universitätsklinik Marien Hospital Herne (DE)
- University Hospital Münster (DE)
- Universitätsklinikum Knappschaftskrankenhaus Bochum (DE)
- Herford Hospital (DE)
- LWL-Universitätsklinikum Bochum (DE)
- Institute of Virology of the Slovak Academy of Sciences (SK)
- Ruhr University Bochum (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Critical Care
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1186/s13054-025-05639-6
- Citations
- 4
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Ruhr-Universität Bochum